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GRIK3 has not been detected as a mutational cancer driver

GRIK3
Ensembl id ENSG00000163873
Mutated samples
Coding Sequence 149 (2.2%)
Protein Affecting 100 (1.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all GRIK3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 40 22 5.96
Colorectal adenocarcinoma No 14 13 5.68
Lung adenocarcinoma No 15 11 2.81
Lung squamous cell carcinoma No 13 10 5.75
Breast carcinoma No 10 8 0.70
Stomach adenocarcinoma No 6 5 3.11
Small cell lung carcinoma No 5 5 7.25
Head and neck squamous cell carcinoma No 7 5 1.33
Uterine corpus endometrioid carcinoma No 7 4 1.74
Glioblastoma multiforme No 5 4 1.06
Bladder carcinoma No 5 2 2.04
Renal clear cell carcinoma No 2 2 0.48
Serous ovarian adenocarcinoma No 5 2 0.63
Esophageal carcinoma No 3 2 1.37
Prostate adenocarcinoma No 1 1 0.41
Acute myeloid leukemia No 1 1 0.51
Thyroid carcinoma No 2 1 0.31
Multiple myeloma No 1 1 1.45
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 2 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence