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GRID2 has not been detected as a mutational cancer driver

GRID2
Ensembl id ENSG00000152208
Mutated samples
Coding Sequence 227 (3.3%)
Protein Affecting 159 (2.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all GRID2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 81 59 15.99
Lung adenocarcinoma No 23 17 4.35
Head and neck squamous cell carcinoma No 16 15 4.00
Lung squamous cell carcinoma No 13 11 6.32
Breast carcinoma No 9 9 0.78
Stomach adenocarcinoma No 7 7 4.35
Esophageal carcinoma No 8 7 4.79
Small cell lung carcinoma No 5 5 7.25
Colorectal adenocarcinoma No 6 5 2.18
Prostate adenocarcinoma No 4 4 1.65
Renal clear cell carcinoma No 4 4 0.96
Uterine corpus endometrioid carcinoma No 4 3 1.30
Bladder carcinoma No 3 2 2.04
Multiple myeloma No 2 2 2.90
Serous ovarian adenocarcinoma No 3 2 0.63
Glioblastoma multiforme No 2 2 0.53
Hepatocarcinoma No 3 1 1.11
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 27 1 0.34
Lower grade glioma No 1 1 0.59
Diffuse B cell lymphoma No 1 1 4.35
Non small cell lung carcinoma No 1 0 0.00
Pylocytic astrocytoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence