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GRIA2 has not been detected as a mutational cancer driver

GRIA2
Ensembl id ENSG00000120251
Mutated samples
Coding Sequence 161 (2.4%)
Protein Affecting 115 (1.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all GRIA2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 52 40 10.84
Lung adenocarcinoma No 17 13 3.32
Head and neck squamous cell carcinoma No 13 12 3.20
Stomach adenocarcinoma No 11 8 4.97
Esophageal carcinoma No 8 7 4.79
Breast carcinoma No 7 6 0.52
Lung squamous cell carcinoma No 9 4 2.30
Small cell lung carcinoma No 4 4 5.80
Renal clear cell carcinoma No 5 3 0.72
Uterine corpus endometrioid carcinoma No 3 3 1.30
Colorectal adenocarcinoma No 4 3 1.31
Prostate adenocarcinoma No 3 2 0.82
Hepatocarcinoma No 3 2 2.22
Thyroid carcinoma No 2 2 0.62
Serous ovarian adenocarcinoma No 2 2 0.63
Bladder carcinoma No 2 1 1.02
Neuroblastoma No 1 1 0.48
Multiple myeloma No 1 1 1.45
Diffuse B cell lymphoma No 1 1 4.35
Non small cell lung carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 9 0 0.00
Glioblastoma multiforme No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence