GREM2 has not been detected as a mutational cancer driver

Ensembl id ENSG00000180875
Mutated samples
Coding Sequence 39 (0.6%)
Protein Affecting 18 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all GREM2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma No 5 4 1.07
Lung adenocarcinoma No 3 3 0.77
Cutaneous melanoma No 9 3 0.81
Breast carcinoma No 3 2 0.17
Lung squamous cell carcinoma No 2 2 1.15
Stomach adenocarcinoma No 4 2 1.24
Acute myeloid leukemia No 1 1 0.51
Esophageal carcinoma No 3 1 0.68
Uterine corpus endometrioid carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 4 0 0.00
Lower grade glioma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence