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GPR39 has not been detected as a mutational cancer driver

GPR39
Ensembl id ENSG00000183840
Mutated samples
Coding Sequence 75 (1.1%)
Protein Affecting 35 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all GPR39 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 31 16 4.34
Head and neck squamous cell carcinoma No 6 5 1.33
Stomach adenocarcinoma No 5 4 2.48
Lung adenocarcinoma No 3 2 0.51
Bladder carcinoma No 2 2 2.04
Lung squamous cell carcinoma No 3 2 1.15
Prostate adenocarcinoma No 1 1 0.41
Renal clear cell carcinoma No 2 1 0.24
Uterine corpus endometrioid carcinoma No 4 1 0.43
Chronic lymphocytic leukemia No 9 1 0.34
Hepatocarcinoma No 2 0 0.00
Breast carcinoma No 4 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Lower grade glioma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence