Top

GNAS is detected as a mutational cancer driver in Esophageal Adenocarcinoma

GNAS reports in Esophageal Adenocarcinoma (ESCA)

Cancer type details
Esophageal Adenocarcinoma
Cohorts 8
Samples 1,139
Mutations 17,905,104
Driver genes 90
Gene details
GNAS
Ensembl ID ENSG00000087460
Transcript ID ENST00000371100
Protein ID ENSP00000360141
Cohorts where is driver 1
Mutated samples 11
Mutated samples (%) 0.97
Mutations 50
Mode of action Loss of function
Known driver True
Method signals per Cohort
Cohort Methods Samples Samples (%)
ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed mutations along the protein sequence.
Mutation (GRCh38) Protein Position Samples Samples (%) Consequence