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GLI2 has not been detected as a mutational cancer driver

GLI2
Ensembl id ENSG00000074047
Mutated samples
Coding Sequence 141 (2.1%)
Protein Affecting 97 (1.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all GLI2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 52 36 9.76
Lung adenocarcinoma No 12 9 2.30
Serous ovarian adenocarcinoma No 7 7 2.22
Head and neck squamous cell carcinoma No 9 7 1.87
Stomach adenocarcinoma No 10 6 3.73
Breast carcinoma No 7 5 0.44
Lung squamous cell carcinoma No 6 5 2.87
Renal clear cell carcinoma No 4 4 0.96
Thyroid carcinoma No 3 3 0.93
Glioblastoma multiforme No 3 3 0.79
Prostate adenocarcinoma No 5 2 0.82
Medulloblastoma No 2 2 0.95
Uterine corpus endometrioid carcinoma No 4 2 0.87
Small cell lung carcinoma No 2 2 2.90
Colorectal adenocarcinoma No 2 2 0.87
Bladder carcinoma No 2 1 1.02
Pancreas adenocarcinoma No 1 1 0.47
Hepatocarcinoma No 2 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 3 0 0.00
Lower grade glioma No 1 0 0.00
Pylocytic astrocytoma No 2 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence