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GABRA4 has not been detected as a mutational cancer driver

GABRA4
Ensembl id ENSG00000109158
Mutated samples
Coding Sequence 89 (1.3%)
Protein Affecting 62 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all GABRA4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 18 15 4.07
Lung adenocarcinoma No 10 8 2.05
Lung squamous cell carcinoma No 6 5 2.87
Small cell lung carcinoma No 4 4 5.80
Glioblastoma multiforme No 6 4 1.06
Bladder carcinoma No 4 3 3.06
Uterine corpus endometrioid carcinoma No 5 3 1.30
Head and neck squamous cell carcinoma No 6 3 0.80
Esophageal carcinoma No 3 3 2.05
Breast carcinoma No 4 2 0.17
Renal clear cell carcinoma No 2 2 0.48
Non small cell lung carcinoma No 2 2 6.45
Stomach adenocarcinoma No 4 2 1.24
Colorectal adenocarcinoma No 4 2 0.87
Acute myeloid leukemia No 1 1 0.51
Pancreas adenocarcinoma No 1 1 0.47
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 2 1 0.32
Hepatocarcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence