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GABRA2 has not been detected as a mutational cancer driver

GABRA2
Ensembl id ENSG00000151834
Mutated samples
Coding Sequence 120 (1.8%)
Protein Affecting 75 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all GABRA2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 33 20 5.42
Lung adenocarcinoma No 16 14 3.58
Lung squamous cell carcinoma No 12 10 5.75
Head and neck squamous cell carcinoma No 10 8 2.13
Breast carcinoma No 5 5 0.44
Esophageal carcinoma No 7 5 3.42
Chronic lymphocytic leukemia No 13 3 1.03
Serous ovarian adenocarcinoma No 2 2 0.63
Bladder carcinoma No 2 1 1.02
Pancreas adenocarcinoma No 1 1 0.47
Uterine corpus endometrioid carcinoma No 2 1 0.43
Stomach adenocarcinoma No 1 1 0.62
Small cell lung carcinoma No 2 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Diffuse B cell lymphoma No 3 1 4.35
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 7 0 0.00
Medulloblastoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence