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FXR1 mutations in 6 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung adenocarcinoma, Lung squamous cell carcinoma, Cutaneous melanoma, Uterine corpus endometrioid carcinoma, Multiple myeloma, Colorectal adenocarcinoma

FXR1
Ensembl id ENSG00000114416
Mutated samples
Coding Sequence 56 (0.8%)
Protein Affecting 38 (0.6%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FXR1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 9 5 1.36
Lung squamous cell carcinoma Yes 6 4 2.30
Uterine corpus endometrioid carcinoma Yes 3 3 1.30
Lung adenocarcinoma Yes 3 2 0.51
Multiple myeloma Yes 2 2 2.90
Colorectal adenocarcinoma Yes 2 2 0.87
Breast carcinoma No 7 6 0.52
Head and neck squamous cell carcinoma No 7 6 1.60
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 2 1 1.11
Bladder carcinoma No 3 1 1.02
Thyroid carcinoma No 1 1 0.31
Non small cell lung carcinoma No 1 1 3.23
Stomach adenocarcinoma No 2 1 0.62
Diffuse B cell lymphoma No 1 1 4.35
Glioblastoma multiforme No 1 1 0.26
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence