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FRAS1 has not been detected as a mutational cancer driver

FRAS1
Ensembl id ENSG00000138759
Mutated samples
Coding Sequence 273 (4.0%)
Protein Affecting 201 (3.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FRAS1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 82 59 15.99
Lung adenocarcinoma No 31 29 7.42
Head and neck squamous cell carcinoma No 17 14 3.73
Glioblastoma multiforme No 21 14 3.69
Stomach adenocarcinoma No 14 11 6.83
Bladder carcinoma No 12 9 9.18
Breast carcinoma No 12 9 0.78
Uterine corpus endometrioid carcinoma No 11 9 3.91
Lung squamous cell carcinoma No 10 8 4.60
Hepatocarcinoma No 6 5 5.56
Medulloblastoma No 5 5 2.38
Renal clear cell carcinoma No 5 5 1.20
Neuroblastoma No 4 4 1.90
Lower grade glioma No 5 4 2.37
Serous ovarian adenocarcinoma No 5 4 1.27
Esophageal carcinoma No 5 4 2.74
Colorectal adenocarcinoma No 4 3 1.31
Prostate adenocarcinoma No 4 2 0.82
Multiple myeloma No 3 1 1.45
Small cell lung carcinoma No 1 1 1.45
Acute lymphocytic leukemia No 1 1 0.82
Acute myeloid leukemia No 1 0 0.00
Thyroid carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 10 0 0.00
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence