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FOXP1 mutations in 6 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Breast carcinoma, Lung squamous cell carcinoma, Cutaneous melanoma, Stomach adenocarcinoma, Colorectal adenocarcinoma, Head and neck squamous cell carcinoma

FOXP1
Ensembl id ENSG00000114861
Mutated samples
Coding Sequence 78 (1.1%)
Protein Affecting 51 (0.8%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FOXP1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 18 12 3.25
Breast carcinoma Yes 10 9 0.78
Head and neck squamous cell carcinoma Yes 6 6 1.60
Lung squamous cell carcinoma Yes 5 4 2.30
Stomach adenocarcinoma Yes 4 4 2.48
Colorectal adenocarcinoma Yes 3 3 1.31
Prostate adenocarcinoma No 5 4 1.65
Uterine corpus endometrioid carcinoma No 6 4 1.74
Lung adenocarcinoma No 2 1 0.26
Bladder carcinoma No 1 1 1.02
Acute myeloid leukemia No 1 1 0.51
Chronic lymphocytic leukemia No 10 1 0.34
Lower grade glioma No 1 1 0.59
Hepatocarcinoma No 4 0 0.00
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence