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FN1 is detected as a mutational cancer driver in 2 cancer types: Lung adenocarcinoma, Lung squamous cell carcinoma and in the PAN-cancer analysis

FN1
Ensembl id ENSG00000115414
Mutated samples
Coding Sequence 172 (2.5%)
Protein Affecting 134 (2.0%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
LUAD F
LUSC F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FN1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 34 22 5.96
Lung squamous cell carcinoma Yes 19 17 9.77
Head and neck squamous cell carcinoma Yes 15 14 3.73
Lung adenocarcinoma Yes 14 13 3.32
Colorectal adenocarcinoma Yes 12 10 4.37
Breast carcinoma Yes 9 7 0.61
Bladder carcinoma Yes 4 4 4.08
Glioblastoma multiforme Yes 4 4 1.06
Small cell lung carcinoma Yes 3 3 4.35
Prostate adenocarcinoma Yes 2 2 0.82
Uterine corpus endometrioid carcinoma No 15 13 5.65
Stomach adenocarcinoma No 10 6 3.73
Esophageal carcinoma No 8 5 3.42
Renal clear cell carcinoma No 6 4 0.96
Hepatocarcinoma No 6 2 2.22
Pancreas adenocarcinoma No 2 2 0.93
Acute myeloid leukemia No 1 1 0.51
Thyroid carcinoma No 1 1 0.31
Non small cell lung carcinoma No 2 1 3.23
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 1 1 0.32
Acute lymphocytic leukemia No 1 1 0.82
Chronic lymphocytic leukemia No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence