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FMO1 has not been detected as a mutational cancer driver

FMO1
Ensembl id ENSG00000010932
Mutated samples
Coding Sequence 81 (1.2%)
Protein Affecting 55 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FMO1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 34 21 5.69
Lung adenocarcinoma No 9 9 2.30
Breast carcinoma No 10 6 0.52
Lung squamous cell carcinoma No 6 4 2.30
Uterine corpus endometrioid carcinoma No 3 2 0.87
Stomach adenocarcinoma No 3 2 1.24
Small cell lung carcinoma No 2 2 2.90
Colorectal adenocarcinoma No 2 2 0.87
Head and neck squamous cell carcinoma No 2 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Renal clear cell carcinoma No 1 1 0.24
Lower grade glioma No 1 1 0.59
Diffuse B cell lymphoma No 1 1 4.35
Esophageal carcinoma No 3 1 0.68
Bladder carcinoma No 1 0 0.00
Medulloblastoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence