Top
FLG has not been detected as a mutational cancer driver

FLG
Ensembl id ENSG00000143631
Mutated samples
Coding Sequence 596 (8.8%)
Protein Affecting 504 (7.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FLG gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 110 100 27.10
Lung adenocarcinoma No 67 59 15.09
Head and neck squamous cell carcinoma No 55 50 13.33
Breast carcinoma No 54 45 3.92
Stomach adenocarcinoma No 42 37 22.98
Lung squamous cell carcinoma No 39 33 18.97
Glioblastoma multiforme No 43 32 8.44
Esophageal carcinoma No 31 28 19.18
Bladder carcinoma No 20 19 19.39
Uterine corpus endometrioid carcinoma No 27 18 7.83
Colorectal adenocarcinoma No 21 16 6.99
Small cell lung carcinoma No 14 12 17.39
Renal clear cell carcinoma No 13 11 2.64
Serous ovarian adenocarcinoma No 11 8 2.53
Lower grade glioma No 10 7 4.14
Prostate adenocarcinoma No 11 6 2.47
Neuroblastoma No 8 6 2.86
Thyroid carcinoma No 6 4 1.24
Hepatocarcinoma No 3 3 3.33
Pancreas adenocarcinoma No 3 3 1.40
Multiple myeloma No 3 3 4.35
Acute myeloid leukemia No 2 2 1.02
Non small cell lung carcinoma No 2 2 6.45
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence