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FIP1L1 is detected as a mutational cancer driver in 1 cancer type: Prostate adenocarcinoma

FIP1L1
Ensembl id ENSG00000145216
Mutated samples
Coding Sequence 269 (4.0%)
Protein Affecting 77 (1.1%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
PRAD F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FIP1L1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Prostate adenocarcinoma Yes 6 4 1.65
Cutaneous melanoma No 69 17 4.61
Lung adenocarcinoma No 32 9 2.30
Breast carcinoma No 26 7 0.61
Lung squamous cell carcinoma No 15 6 3.45
Renal clear cell carcinoma No 8 5 1.20
Glioblastoma multiforme No 15 5 1.32
Stomach adenocarcinoma No 10 4 2.48
Bladder carcinoma No 11 3 3.06
Uterine corpus endometrioid carcinoma No 10 3 1.30
Lower grade glioma No 5 3 1.78
Small cell lung carcinoma No 5 2 2.90
Colorectal adenocarcinoma No 7 2 0.87
Head and neck squamous cell carcinoma No 10 2 0.53
Hepatocarcinoma No 3 1 1.11
Acute myeloid leukemia No 4 1 0.51
Neuroblastoma No 2 1 0.48
Serous ovarian adenocarcinoma No 7 1 0.32
Esophageal carcinoma No 5 1 0.68
Medulloblastoma No 1 0 0.00
Thyroid carcinoma No 3 0 0.00
Chronic lymphocytic leukemia No 10 0 0.00
Multiple myeloma No 1 0 0.00
Pylocytic astrocytoma No 4 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence