IntOGen - FBXW7 gene cancer mutations in PAAD

FBXW7 is detected as a mutational cancer driver in Pancreatic Adenocarcinoma

FBXW7 reports in Pancreatic Adenocarcinoma (PAAD)

Methods
Mutation distribution

Cancer type details

Pancreatic Adenocarcinoma
Cohorts 7 Samples 922 Mutations 2,520,434 Driver genes 64

Gene details

FBXW7
Ensembl ID ENSG00000109670 Transcript ID ENST00000603548 Protein ID ENSP00000474725
Cohorts where is driver 3 Mutated samples 10 Mutated samples (%) 1.08 Mutations 11
Mode of action Loss of function
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence