IntOGen - FAT4 gene cancer mutations in SCLC

FAT4 is detected as a mutational cancer driver in Small Cell Lung Cancer

FAT4 reports in Small Cell Lung Cancer (SCLC)

Methods
Mutation distribution

Cancer type details

Small Cell Lung Cancer
Cohorts 3 Samples 188 Mutations 2,426,920 Driver genes 24

Gene details

FAT4
Ensembl ID ENSG00000196159 Transcript ID ENST00000674496 Protein ID ENSP00000501473
Cohorts where is driver 2 Mutated samples 11 Mutated samples (%) 5.85 Mutations 28
Mode of action Loss of function
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence