IntOGen - FAT3 gene cancer mutations

FAT3 is detected as a mutational cancer driver

FAT3 reports

Methods
Mutation distribution

Gene details

FAT3
Ensembl ID ENSG00000165323 Transcript ID ENST00000409404 Protein ID ENSP00000387040
Cancer types where is driver 18 Cohorts where is driver 25 Mutated samples 376 Mutations 3,001
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence