IntOGen - FANCD2 gene cancer mutations

FANCD2 is detected as a mutational cancer driver

FANCD2 reports

Methods
Mutation distribution

Gene details

FANCD2
Ensembl ID ENSG00000144554 Transcript ID ENST00000287647 Protein ID ENSP00000287647
Cancer types where is driver 1 Cohorts where is driver 1 Mutated samples 10 Mutations 494
Mode of action Ambiguous
Known driver False

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence