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FAM46C is detected as a mutational cancer driver in 1 cancer type: Multiple myeloma

FAM46C
Ensembl id ENSG00000183508
Mutated samples
Coding Sequence 44 (0.6%)
Protein Affecting 31 (0.5%)
Mode of action Unclassified
Known driver Yes
Cancer type Signals (Biases)
MM F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all FAM46C gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Multiple myeloma Yes 8 7 10.14
Cutaneous melanoma No 12 8 2.17
Uterine corpus endometrioid carcinoma No 5 4 1.74
Stomach adenocarcinoma No 3 3 1.86
Glioblastoma multiforme No 3 3 0.79
Head and neck squamous cell carcinoma No 5 2 0.53
Lung adenocarcinoma No 2 1 0.26
Lung squamous cell carcinoma No 1 1 0.57
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Medulloblastoma No 1 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence