IntOGen - ERBB4 gene cancer mutations in STAD

ERBB4 is detected as a mutational cancer driver in Stomach Adenocarcinoma

ERBB4 reports in Stomach Adenocarcinoma (STAD)

Methods
Mutation distribution

Cancer type details

Stomach Adenocarcinoma
Cohorts 6 Samples 858 Mutations 6,723,174 Driver genes 75

Gene details

ERBB4
Ensembl ID ENSG00000178568 Transcript ID ENST00000342788 Protein ID ENSP00000342235
Cohorts where is driver 2 Mutated samples 40 Mutated samples (%) 4.66 Mutations 62
Mode of action Activating
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence