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ERBB4 has not been detected as a mutational cancer driver

ERBB4
Ensembl id ENSG00000178568
Mutated samples
Coding Sequence 270 (4.0%)
Protein Affecting 189 (2.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ERBB4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 74 52 14.09
Lung adenocarcinoma No 29 26 6.65
Stomach adenocarcinoma No 18 17 10.56
Head and neck squamous cell carcinoma No 18 15 4.00
Esophageal carcinoma No 17 15 10.27
Breast carcinoma No 14 12 1.05
Lung squamous cell carcinoma No 11 9 5.17
Colorectal adenocarcinoma No 12 9 3.93
Small cell lung carcinoma No 9 8 11.59
Renal clear cell carcinoma No 6 6 1.44
Uterine corpus endometrioid carcinoma No 8 6 2.61
Hepatocarcinoma No 11 4 4.44
Bladder carcinoma No 3 2 2.04
Non small cell lung carcinoma No 2 2 6.45
Prostate adenocarcinoma No 2 1 0.41
Pancreas adenocarcinoma No 1 1 0.47
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 25 1 0.34
Diffuse B cell lymphoma No 2 1 4.35
Glioblastoma multiforme No 1 1 0.26
Medulloblastoma No 1 0 0.00
Multiple myeloma No 1 0 0.00
Pylocytic astrocytoma No 4 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence