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EPHB2 is detected as a mutational cancer driver in 1 cancer type: Lung adenocarcinoma

EPHB2
Ensembl id ENSG00000133216
Mutated samples
Coding Sequence 113 (1.7%)
Protein Affecting 75 (1.1%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
LUAD F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all EPHB2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma Yes 6 6 1.53
Cutaneous melanoma No 42 26 7.05
Breast carcinoma No 10 7 0.61
Stomach adenocarcinoma No 10 7 4.35
Lung squamous cell carcinoma No 7 5 2.87
Uterine corpus endometrioid carcinoma No 8 4 1.74
Bladder carcinoma No 3 3 3.06
Colorectal adenocarcinoma No 3 3 1.31
Glioblastoma multiforme No 3 3 0.79
Prostate adenocarcinoma No 2 2 0.82
Serous ovarian adenocarcinoma No 4 2 0.63
Head and neck squamous cell carcinoma No 3 2 0.53
Pancreas adenocarcinoma No 2 1 0.47
Renal clear cell carcinoma No 2 1 0.24
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 5 1 0.34
Esophageal carcinoma No 1 1 0.68
Small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence