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EPHA8 has not been detected as a mutational cancer driver

EPHA8
Ensembl id ENSG00000070886
Mutated samples
Coding Sequence 100 (1.5%)
Protein Affecting 59 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all EPHA8 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 31 17 4.61
Stomach adenocarcinoma No 9 7 4.35
Lung squamous cell carcinoma No 8 6 3.45
Lung adenocarcinoma No 11 5 1.28
Renal clear cell carcinoma No 7 4 0.96
Uterine corpus endometrioid carcinoma No 5 4 1.74
Glioblastoma multiforme No 7 4 1.06
Esophageal carcinoma No 5 4 2.74
Colorectal adenocarcinoma No 2 2 0.87
Bladder carcinoma No 2 1 1.02
Acute myeloid leukemia No 1 1 0.51
Breast carcinoma No 2 1 0.09
Neuroblastoma No 1 1 0.48
Small cell lung carcinoma No 1 1 1.45
Head and neck squamous cell carcinoma No 6 1 0.27
Prostate adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence