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EPHA4 is detected as a mutational cancer driver in 1 cancer type: Lung adenocarcinoma

EPHA4
Ensembl id ENSG00000116106
Mutated samples
Coding Sequence 104 (1.5%)
Protein Affecting 67 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
LUAD F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all EPHA4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma Yes 8 8 2.05
Cutaneous melanoma No 42 21 5.69
Head and neck squamous cell carcinoma No 11 9 2.40
Esophageal carcinoma No 6 6 4.11
Uterine corpus endometrioid carcinoma No 5 4 1.74
Stomach adenocarcinoma No 8 4 2.48
Colorectal adenocarcinoma No 4 3 1.31
Hepatocarcinoma No 3 2 2.22
Breast carcinoma No 2 2 0.17
Lower grade glioma No 2 2 1.18
Small cell lung carcinoma No 2 2 2.90
Prostate adenocarcinoma No 1 1 0.41
Lung squamous cell carcinoma No 3 1 0.57
Pancreas adenocarcinoma No 1 1 0.47
Glioblastoma multiforme No 1 1 0.26
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 3 0 0.00
Multiple myeloma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence