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ENPEP has not been detected as a mutational cancer driver

ENPEP
Ensembl id ENSG00000138792
Mutated samples
Coding Sequence 148 (2.2%)
Protein Affecting 87 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ENPEP gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 60 22 5.96
Head and neck squamous cell carcinoma No 15 12 3.20
Lung squamous cell carcinoma No 12 10 5.75
Lung adenocarcinoma No 6 6 1.53
Breast carcinoma No 4 4 0.35
Renal clear cell carcinoma No 4 4 0.96
Glioblastoma multiforme No 5 4 1.06
Bladder carcinoma No 3 3 3.06
Thyroid carcinoma No 4 3 0.93
Uterine corpus endometrioid carcinoma No 5 3 1.30
Colorectal adenocarcinoma No 4 3 1.31
Chronic lymphocytic leukemia No 6 2 0.69
Stomach adenocarcinoma No 2 2 1.24
Esophageal carcinoma No 3 2 1.37
Prostate adenocarcinoma No 1 1 0.41
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 1 1 1.45
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 2 1 1.45
Diffuse B cell lymphoma No 1 1 4.35
Hepatocarcinoma No 3 0 0.00
Acute myeloid leukemia No 1 0 0.00
Pylocytic astrocytoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence