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ELF3 is detected as a mutational cancer driver in 2 cancer types: Bladder carcinoma, Colorectal adenocarcinoma and in the PAN-cancer analysis

ELF3
Ensembl id ENSG00000163435
Mutated samples
Coding Sequence 54 (0.8%)
Protein Affecting 32 (0.5%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
BLCA FR
COREAD FR
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ELF3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Bladder carcinoma Yes 8 8 8.16
Colorectal adenocarcinoma Yes 7 7 3.06
Stomach adenocarcinoma Yes 5 4 2.48
Cutaneous melanoma Yes 12 2 0.54
Esophageal carcinoma Yes 3 2 1.37
Breast carcinoma No 4 3 0.26
Lung adenocarcinoma No 2 1 0.26
Hepatocarcinoma No 2 1 1.11
Thyroid carcinoma No 1 1 0.31
Uterine corpus endometrioid carcinoma No 1 1 0.43
Serous ovarian adenocarcinoma No 1 1 0.32
Head and neck squamous cell carcinoma No 2 1 0.27
Medulloblastoma No 2 0 0.00
Lung squamous cell carcinoma No 2 0 0.00
Lower grade glioma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence