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EIF4G1 is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma and in the PAN-cancer analysis

EIF4G1
Ensembl id ENSG00000114867
Mutated samples
Coding Sequence 98 (1.4%)
Protein Affecting 70 (1.0%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
CM F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all EIF4G1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 24 17 4.61
Lung adenocarcinoma Yes 10 9 2.30
Stomach adenocarcinoma Yes 8 4 2.48
Bladder carcinoma Yes 4 3 3.06
Breast carcinoma Yes 5 3 0.26
Renal clear cell carcinoma Yes 3 3 0.72
Uterine corpus endometrioid carcinoma Yes 3 3 1.30
Prostate adenocarcinoma Yes 2 2 0.82
Esophageal carcinoma Yes 3 2 1.37
Head and neck squamous cell carcinoma No 12 9 2.40
Lung squamous cell carcinoma No 9 8 4.60
Glioblastoma multiforme No 3 2 0.53
Thyroid carcinoma No 2 1 0.31
Multiple myeloma No 2 1 1.45
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 2 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Medulloblastoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Serous ovarian adenocarcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence