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EIF4A2 mutations in 9 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung adenocarcinoma, Bladder carcinoma, Breast carcinoma, Lung squamous cell carcinoma, Renal clear cell carcinoma, Cutaneous melanoma, Uterine corpus endometrioid carcinoma, Serous ovarian adenocarcinoma, Stomach adenocarcinoma

EIF4A2
Ensembl id ENSG00000156976
Mutated samples
Coding Sequence 79 (1.2%)
Protein Affecting 39 (0.6%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all EIF4A2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 13 8 0.70
Lung adenocarcinoma Yes 4 4 1.02
Cutaneous melanoma Yes 11 4 1.08
Renal clear cell carcinoma Yes 5 3 0.72
Uterine corpus endometrioid carcinoma Yes 5 3 1.30
Stomach adenocarcinoma Yes 4 3 1.86
Bladder carcinoma Yes 6 2 2.04
Lung squamous cell carcinoma Yes 7 2 1.15
Serous ovarian adenocarcinoma Yes 2 2 0.63
Colorectal adenocarcinoma No 7 4 1.75
Multiple myeloma No 1 1 1.45
Small cell lung carcinoma No 1 1 1.45
Esophageal carcinoma No 3 1 0.68
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 2 0 0.00
Head and neck squamous cell carcinoma No 4 0 0.00
Diffuse B cell lymphoma No 2 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence