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EIF2B5 has not been detected as a mutational cancer driver

EIF2B5
Ensembl id ENSG00000145191
Mutated samples
Coding Sequence 603 (8.9%)
Protein Affecting 22 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all EIF2B5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Serous ovarian adenocarcinoma No 21 4 1.27
Lung squamous cell carcinoma No 50 3 1.72
Cutaneous melanoma No 129 3 0.81
Bladder carcinoma No 20 2 2.04
Stomach adenocarcinoma No 36 2 1.24
Head and neck squamous cell carcinoma No 59 2 0.53
Breast carcinoma No 57 1 0.09
Renal clear cell carcinoma No 21 1 0.24
Neuroblastoma No 3 1 0.48
Small cell lung carcinoma No 15 1 1.45
Colorectal adenocarcinoma No 16 1 0.44
Esophageal carcinoma No 23 1 0.68
Prostate adenocarcinoma No 11 0 0.00
Lung adenocarcinoma No 48 0 0.00
Hepatocarcinoma No 6 0 0.00
Medulloblastoma No 5 0 0.00
Thyroid carcinoma No 8 0 0.00
Uterine corpus endometrioid carcinoma No 34 0 0.00
Non small cell lung carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 11 0 0.00
Multiple myeloma No 5 0 0.00
Lower grade glioma No 2 0 0.00
Pylocytic astrocytoma No 4 0 0.00
Glioblastoma multiforme No 16 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence