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EIF2AK3 is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma and in the PAN-cancer analysis

EIF2AK3
Ensembl id ENSG00000172071
Mutated samples
Coding Sequence 74 (1.1%)
Protein Affecting 65 (1.0%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
CM F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all EIF2AK3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 22 21 5.69
Lung adenocarcinoma Yes 5 5 1.28
Stomach adenocarcinoma Yes 6 5 3.11
Small cell lung carcinoma Yes 4 4 5.80
Prostate adenocarcinoma Yes 3 3 1.23
Serous ovarian adenocarcinoma Yes 3 3 0.95
Bladder carcinoma Yes 4 2 2.04
Renal clear cell carcinoma Yes 2 2 0.48
Uterine corpus endometrioid carcinoma Yes 2 2 0.87
Esophageal carcinoma Yes 2 2 1.37
Lung squamous cell carcinoma No 7 6 3.45
Breast carcinoma No 4 3 0.26
Head and neck squamous cell carcinoma No 3 2 0.53
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Lower grade glioma No 1 1 0.59
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence