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EDAR has not been detected as a mutational cancer driver

EDAR
Ensembl id ENSG00000135960
Mutated samples
Coding Sequence 54 (0.8%)
Protein Affecting 28 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all EDAR gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 18 6 1.63
Stomach adenocarcinoma No 7 6 3.73
Lung adenocarcinoma No 4 3 0.77
Breast carcinoma No 5 3 0.26
Lung squamous cell carcinoma No 2 2 1.15
Lower grade glioma No 3 2 1.18
Neuroblastoma No 1 1 0.48
Uterine corpus endometrioid carcinoma No 1 1 0.43
Multiple myeloma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Head and neck squamous cell carcinoma No 2 1 0.27
Glioblastoma multiforme No 2 1 0.26
Hepatocarcinoma No 1 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 4 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence