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DSPP has not been detected as a mutational cancer driver

DSPP
Ensembl id ENSG00000152591
Mutated samples
Coding Sequence 69 (1.0%)
Protein Affecting 53 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DSPP gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 27 26 7.05
Breast carcinoma No 12 6 0.52
Lung adenocarcinoma No 5 4 1.02
Lung squamous cell carcinoma No 4 3 1.72
Bladder carcinoma No 3 2 2.04
Uterine corpus endometrioid carcinoma No 5 2 0.87
Stomach adenocarcinoma No 2 2 1.24
Small cell lung carcinoma No 2 2 2.90
Colorectal adenocarcinoma No 2 2 0.87
Esophageal carcinoma No 2 2 1.37
Neuroblastoma No 1 1 0.48
Acute lymphocytic leukemia No 1 1 0.82
Lower grade glioma No 1 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence