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DPYD has not been detected as a mutational cancer driver

DPYD
Ensembl id ENSG00000188641
Mutated samples
Coding Sequence 181 (2.7%)
Protein Affecting 126 (1.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DPYD gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 85 66 17.89
Lung adenocarcinoma No 7 7 1.79
Stomach adenocarcinoma No 11 7 4.35
Head and neck squamous cell carcinoma No 10 7 1.87
Esophageal carcinoma No 6 6 4.11
Colorectal adenocarcinoma No 5 5 2.18
Lung squamous cell carcinoma No 6 4 2.30
Uterine corpus endometrioid carcinoma No 4 4 1.74
Bladder carcinoma No 3 3 3.06
Serous ovarian adenocarcinoma No 4 3 0.95
Small cell lung carcinoma No 3 3 4.35
Prostate adenocarcinoma No 2 2 0.82
Breast carcinoma No 3 2 0.17
Medulloblastoma No 2 2 0.95
Renal clear cell carcinoma No 3 2 0.48
Glioblastoma multiforme No 2 2 0.53
Neuroblastoma No 1 1 0.48
Hepatocarcinoma No 3 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 16 0 0.00
Pylocytic astrocytoma No 3 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence