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DOCK7 has not been detected as a mutational cancer driver

DOCK7
Ensembl id ENSG00000116641
Mutated samples
Coding Sequence 132 (1.9%)
Protein Affecting 81 (1.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DOCK7 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 21 15 4.07
Head and neck squamous cell carcinoma No 13 10 2.67
Lung adenocarcinoma No 11 8 2.05
Breast carcinoma No 13 8 0.70
Uterine corpus endometrioid carcinoma No 9 7 3.04
Stomach adenocarcinoma No 14 6 3.73
Lung squamous cell carcinoma No 10 5 2.87
Renal clear cell carcinoma No 7 4 0.96
Bladder carcinoma No 4 3 3.06
Prostate adenocarcinoma No 2 2 0.82
Chronic lymphocytic leukemia No 4 2 0.69
Lower grade glioma No 3 2 1.18
Serous ovarian adenocarcinoma No 3 2 0.63
Esophageal carcinoma No 2 2 1.37
Medulloblastoma No 1 1 0.48
Thyroid carcinoma No 1 1 0.31
Multiple myeloma No 2 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 2 1 0.26
Hepatocarcinoma No 5 0 0.00
Non small cell lung carcinoma No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence