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DOCK3 has not been detected as a mutational cancer driver

DOCK3
Ensembl id ENSG00000088538
Mutated samples
Coding Sequence 214 (3.2%)
Protein Affecting 141 (2.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DOCK3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 87 56 15.18
Stomach adenocarcinoma No 15 13 8.07
Uterine corpus endometrioid carcinoma No 12 10 4.35
Lung adenocarcinoma No 14 9 2.30
Breast carcinoma No 13 8 0.70
Head and neck squamous cell carcinoma No 10 8 2.13
Lung squamous cell carcinoma No 7 6 3.45
Renal clear cell carcinoma No 7 6 1.44
Serous ovarian adenocarcinoma No 6 5 1.58
Hepatocarcinoma No 7 4 4.44
Prostate adenocarcinoma No 4 3 1.23
Colorectal adenocarcinoma No 3 3 1.31
Bladder carcinoma No 4 2 2.04
Neuroblastoma No 2 2 0.95
Medulloblastoma No 1 1 0.48
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 1 1 0.31
Small cell lung carcinoma No 1 1 1.45
Glioblastoma multiforme No 4 1 0.26
Esophageal carcinoma No 6 1 0.68
Chronic lymphocytic leukemia No 9 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence