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DOCK10 has not been detected as a mutational cancer driver

DOCK10
Ensembl id ENSG00000135905
Mutated samples
Coding Sequence 144 (2.1%)
Protein Affecting 103 (1.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DOCK10 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 22 15 4.07
Lung squamous cell carcinoma No 15 14 8.05
Breast carcinoma No 14 11 0.96
Lung adenocarcinoma No 16 10 2.56
Head and neck squamous cell carcinoma No 12 9 2.40
Stomach adenocarcinoma No 8 8 4.97
Uterine corpus endometrioid carcinoma No 7 6 2.61
Esophageal carcinoma No 9 6 4.11
Renal clear cell carcinoma No 9 5 1.20
Bladder carcinoma No 5 3 3.06
Multiple myeloma No 3 3 4.35
Glioblastoma multiforme No 4 3 0.79
Prostate adenocarcinoma No 3 2 0.82
Serous ovarian adenocarcinoma No 2 2 0.63
Colorectal adenocarcinoma No 2 2 0.87
Acute myeloid leukemia No 1 1 0.51
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 1 1 0.31
Small cell lung carcinoma No 1 1 1.45
Medulloblastoma No 2 0 0.00
Chronic lymphocytic leukemia No 6 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence