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DNASE1L3 has not been detected as a mutational cancer driver

DNASE1L3
Ensembl id ENSG00000163687
Mutated samples
Coding Sequence 31 (0.5%)
Protein Affecting 17 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DNASE1L3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 14 6 1.63
Breast carcinoma No 5 5 0.44
Lung adenocarcinoma No 2 2 0.51
Small cell lung carcinoma No 2 2 2.90
Colorectal adenocarcinoma No 2 2 0.87
Hepatocarcinoma No 1 0 0.00
Thyroid carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Stomach adenocarcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence