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DHX57 has not been detected as a mutational cancer driver

DHX57
Ensembl id ENSG00000163214
Mutated samples
Coding Sequence 79 (1.2%)
Protein Affecting 52 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DHX57 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 26 17 4.61
Lung adenocarcinoma No 12 8 2.05
Uterine corpus endometrioid carcinoma No 9 6 2.61
Prostate adenocarcinoma No 4 4 1.65
Breast carcinoma No 2 2 0.17
Lung squamous cell carcinoma No 3 2 1.15
Renal clear cell carcinoma No 2 2 0.48
Chronic lymphocytic leukemia No 2 2 0.69
Stomach adenocarcinoma No 3 2 1.24
Colorectal adenocarcinoma No 3 2 0.87
Bladder carcinoma No 2 1 1.02
Multiple myeloma No 2 1 1.45
Head and neck squamous cell carcinoma No 2 1 0.27
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 2 1 0.68
Medulloblastoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Lower grade glioma No 1 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence