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DCHS2 has not been detected as a mutational cancer driver

DCHS2
Ensembl id ENSG00000197410
Mutated samples
Coding Sequence 278 (4.1%)
Protein Affecting 198 (2.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all DCHS2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 68 47 12.74
Lung adenocarcinoma No 27 23 5.88
Head and neck squamous cell carcinoma No 24 19 5.07
Breast carcinoma No 23 17 1.48
Stomach adenocarcinoma No 19 15 9.32
Lung squamous cell carcinoma No 15 12 6.90
Uterine corpus endometrioid carcinoma No 14 12 5.22
Esophageal carcinoma No 13 12 8.22
Colorectal adenocarcinoma No 15 9 3.93
Bladder carcinoma No 7 5 5.10
Small cell lung carcinoma No 6 5 7.25
Prostate adenocarcinoma No 9 4 1.65
Renal clear cell carcinoma No 6 4 0.96
Glioblastoma multiforme No 10 4 1.06
Serous ovarian adenocarcinoma No 4 3 0.95
Hepatocarcinoma No 3 2 2.22
Neuroblastoma No 3 2 0.95
Acute myeloid leukemia No 1 1 0.51
Chronic lymphocytic leukemia No 6 1 0.34
Lower grade glioma No 2 1 0.59
Pancreas adenocarcinoma No 1 0 0.00
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence