Top
CYP8B1 has not been detected as a mutational cancer driver

CYP8B1
Ensembl id ENSG00000180432
Mutated samples
Coding Sequence 101 (1.5%)
Protein Affecting 41 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CYP8B1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 40 15 4.07
Breast carcinoma No 7 4 0.35
Renal clear cell carcinoma No 4 3 0.72
Head and neck squamous cell carcinoma No 5 3 0.80
Lung adenocarcinoma No 8 2 0.51
Serous ovarian adenocarcinoma No 2 2 0.63
Stomach adenocarcinoma No 3 2 1.24
Colorectal adenocarcinoma No 8 2 0.87
Glioblastoma multiforme No 5 2 0.53
Esophageal carcinoma No 2 2 1.37
Hepatocarcinoma No 3 1 1.11
Bladder carcinoma No 2 1 1.02
Lung squamous cell carcinoma No 5 1 0.57
Chronic lymphocytic leukemia No 1 1 0.34
Prostate adenocarcinoma No 1 0 0.00
Neuroblastoma No 1 0 0.00
Uterine corpus endometrioid carcinoma No 2 0 0.00
Multiple myeloma No 1 0 0.00
Small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence