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CYP4A22 has not been detected as a mutational cancer driver

CYP4A22
Ensembl id ENSG00000162365
Mutated samples
Coding Sequence 69 (1.0%)
Protein Affecting 47 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CYP4A22 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 39 25 6.78
Head and neck squamous cell carcinoma No 7 5 1.33
Bladder carcinoma No 4 4 4.08
Renal clear cell carcinoma No 3 3 0.72
Breast carcinoma No 4 2 0.17
Lung squamous cell carcinoma No 3 2 1.15
Uterine corpus endometrioid carcinoma No 2 2 0.87
Acute myeloid leukemia No 1 1 0.51
Serous ovarian adenocarcinoma No 1 1 0.32
Stomach adenocarcinoma No 1 1 0.62
Colorectal adenocarcinoma No 1 1 0.44
Lung adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence