IntOGen - CYLD gene cancer mutations in NSCLC

CYLD is detected as a mutational cancer driver in Non-Small Cell Lung Cancer

CYLD reports in Non-Small Cell Lung Cancer (NSCLC)

Methods
Mutation distribution

Cancer type details

Non-Small Cell Lung Cancer
Cohorts 2 Samples 564 Mutations 22,065,649 Driver genes 48

Gene details

CYLD
Ensembl ID ENSG00000083799 Transcript ID ENST00000427738 Protein ID ENSP00000392025
Cohorts where is driver 1 Mutated samples 11 Mutated samples (%) 1.95 Mutations 15
Mode of action Loss of function
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence