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CYLD mutations in 2 Cutaneous melanoma projects possibly contribute to the detection of the gene in the PAN-cancer anlaysis:

Cutaneous melanoma
Projects 2
369 Samples
Coding sequence mutations (CSMs)
in driver genes 4035
in all genes 413513
Protein affecting mutations (PAMs)
in driver genes 2994
in all genes 167055
CYLD
Ensembl id ENSG00000083799
Mutated samples
Coding Sequence 10 (2.7%)
Protein Affecting 8 (2.2%)
Mode of action Loss of function
Known driver Yes
Project Signals
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Cutaneous melanoma projects in all CYLD gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Skin cutaneous melanoma TCGA obtained from Synapse Yes 6 5 1.36
Skin cutaneous melanoma BROAD obtained from Alexandrov Yes 4 3 0.81
The mutations needle plot shows the distribution of the observed CYLD cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification