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CXCR4 has not been detected as a mutational cancer driver

CXCR4
Ensembl id ENSG00000121966
Mutated samples
Coding Sequence 32 (0.5%)
Protein Affecting 20 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CXCR4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung squamous cell carcinoma No 7 5 2.87
Cutaneous melanoma No 6 3 0.81
Colorectal adenocarcinoma No 3 3 1.31
Lung adenocarcinoma No 2 2 0.51
Bladder carcinoma No 2 2 2.04
Medulloblastoma No 1 1 0.48
Renal clear cell carcinoma No 1 1 0.24
Lower grade glioma No 1 1 0.59
Stomach adenocarcinoma No 2 1 0.62
Head and neck squamous cell carcinoma No 1 1 0.27
Chronic lymphocytic leukemia No 3 0 0.00
Diffuse B cell lymphoma No 2 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence