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CUL3 is detected as a mutational cancer driver in 2 cancer types: Lung adenocarcinoma, Head and neck squamous cell carcinoma and in the PAN-cancer analysis

CUL3
Ensembl id ENSG00000036257
Mutated samples
Coding Sequence 66 (1.0%)
Protein Affecting 53 (0.8%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
LUAD F
HNSC F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all CUL3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma Yes 12 12 3.20
Lung adenocarcinoma Yes 6 6 1.53
Stomach adenocarcinoma Yes 5 5 3.11
Cutaneous melanoma Yes 8 4 1.08
Prostate adenocarcinoma Yes 3 3 1.23
Esophageal carcinoma Yes 2 2 1.37
Lung squamous cell carcinoma No 10 9 5.17
Renal clear cell carcinoma No 6 5 1.20
Breast carcinoma No 4 2 0.17
Acute myeloid leukemia No 1 1 0.51
Pancreas adenocarcinoma No 1 1 0.47
Neuroblastoma No 1 1 0.48
Serous ovarian adenocarcinoma No 1 1 0.32
Colorectal adenocarcinoma No 1 1 0.44
Hepatocarcinoma No 1 0 0.00
Uterine corpus endometrioid carcinoma No 2 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence