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CTNNB1 is detected as a mutational cancer driver in 2 Medulloblastoma projects

Medulloblastoma
Projects 2
210 Samples
Coding sequence mutations (CSMs)
in driver genes 161
in all genes 8146
Protein affecting mutations (PAMs)
in driver genes 159
in all genes 2132
CTNNB1
Ensembl id ENSG00000168036
Mutated samples
Coding Sequence 26 (12.4%)
Protein Affecting 26 (12.4%)
Mode of action Activating
Known driver Yes
Project Signals
MB_DKFZ FC
MB_SANGER FC
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Medulloblastoma projects in all CTNNB1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Pediatric brain tumors DKFZ Yes 15 15 7.14
Medulloblastoma tumors obtained from Alexandrov et al. Yes 11 11 5.24
The mutations needle plot shows the distribution of the observed CTNNB1 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification