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CTNNB1 is detected as a mutational cancer driver in 2 Hepatocarcinoma projects

Hepatocarcinoma
Projects 2
90 Samples
Coding sequence mutations (CSMs)
in driver genes 151
in all genes 28172
Protein affecting mutations (PAMs)
in driver genes 104
in all genes 4873
CTNNB1
Ensembl id ENSG00000168036
Mutated samples
Coding Sequence 19 (21.1%)
Protein Affecting 17 (18.9%)
Mode of action Activating
Known driver Yes
Project Signals
HC_ICGC C
HC_IACR C
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Hepatocarcinoma projects in all CTNNB1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Liver cancer IARC Yes 9 9 10.00
Liver Cancer ICGC obtained from AlexandrovEtAl Yes 10 8 8.89
The mutations needle plot shows the distribution of the observed CTNNB1 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification