Top

CTNNB1 is detected as a mutational cancer driver

CTNNB1 reports

Gene details
CTNNB1
Ensembl ID ENSG00000168036
Transcript ID ENST00000645320
Protein ID ENSP00000495360
Cancer types where is driver 17
Cohorts where is driver 45
Mutated samples 879
Mutations 1,214
Mode of action Ambiguous
Known driver True
Method signals per Cancer Type
Cancer type Methods Samples Samples (%)
ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
In-silico saturation mutagenesis
Alt text
In silico saturation mutagenesis profiles across all tumor types where a specific model is available. Driver mutations (displayed as red dots) are mapped to their positions in the canonical transcript. The dendrogram on the right represents a hierarchical clustering of the profiles based on site-by-site concordance via Matthews Correlation similarity. The track on the top displays the Pfam domains mapping to the canonical transcript. See the FAQs for more details about the in silico saturation mutagenesis computed with boostDM.
Model Mutations Driver mutations Driver mutations (%)
HC (Hepatocellular Carcinoma) 7020 233 3.32
LUAD (Lung Adenocarcinoma) 7020 321 4.57
LUNG_CANCER (Lung) 7020 207 2.95
PIA (Pilocytic Astrocytoma) 7020 144 2.05
PRAD (Prostate Adenocarcinoma) 7020 280 3.99
UCEC (Endometrial Carcinoma) 7020 89 1.27
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed mutations along the protein sequence.
Mutation (GRCh38) Protein Position Samples Consequence